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. 2017 Jul 8;14(3):3043–3050. doi: 10.3892/ol.2017.6556

Figure 1.

Figure 1.

PHI and LY294002 inhibit the viability of HL-60 cells. (A) Cell viability was inhibited at various concentrations of PHI in a dose- and time-dependent manner vs. untreated control. (B) Cell viability was inhibited at various concentrations of LY294002 in a dose- and time-dependent manner vs. untreated control. (C) PHI and LY294002 in combination exhibited a synergistic effect on HL-60 cell viability vs. PHI or LY294002 alone. (D) Dose-response curves of the single or combined drug treatments. (E) Fa-CI curve of PHI and LY294002 in combination revealing a synergistic effect with 10, 15, 20, 30 and 40 µmol/l (CI<1). The broken line at CI=1 represents the additive effect. *P<0.05, **P<0.01, ***P<0.001; Fa, affected fraction; CI, combination index.