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. 2017 Jan 18;139(6):2512–2519. doi: 10.1021/jacs.6b13399

Figure 3.

Figure 3

(a,b) Logarithmic fitting curve for cell viability of cHSA-PEO-TPP-Ru and bare Ru complex, over a broad concentration range with and without light. (c) Logarithmic fitting curve for cell viability of cHSA-PEO-Ru complex with light, where mitochondria targeting TPP group were absent. For all of the above experiments, HeLa cells were exposed to a 470 nm LED lamp (∼20 mW/cm2) for 5 min for light irradiation. cHSA-PEO-TPP-Ru reveals low dark toxicity (IC50 = 9 ± 2 μM) but very high phototoxicity (IC50 = 34.9 ± 2 nM) compared to Ru1 (dark IC50 = 203 ± 3 μM; photoirradiated IC50 = 7.7 ± 1.3 μM). In the absence of a TPP group, the phototoxic effect of the drug was reduced by ∼8 times (IC50 = 265 ± 1.2 nM).