Table III.

Univariate and multivariate analyses of overall survival of patients with NCSLC.

	Univariate analysis			Multivariate analysis
Variable	HR	95% CI	P-value	HR	95% CI	P-value
Sex (male vs. female)	0.948	0.660–1.362	0.772	0.968	0.643–1.456	0.875
Age (≤60 vs. >60)	1.159	0.810–1.658	0.419	1.216	0.996–2.681	0.303
Histologic type (adenocarcinoma vs. squamous cell carcinoma)	0.855	0.477–1.529	0.597	1.099	0.574–2.105	0.776
Tumor differentiation (well vs. moderate vs. poor)	0.862	0.462–1.548	0.829	1.289	0.656–1.857	0.721
Tumor size (T1 vs. T2 vs. T3 vs. T4)	1.976	0.425–4.088	0.046a	0.802	0.117–4.740	0.379
Lymph node metastasis (absent vs. present)	1.261	0.441–1.192	0.365	1.543	0.619–3.848	0.352
Lung cancer stages (1 vs. 2 vs. 3)	1.344	1.072–2.466	0.032a	1.815	1.347–2.802	0.041a
SPOP expression (low vs. high)	0.652	0.306–0.861	0.039a	0.634	0.422–0.712	0.045a

^aStatistically significant. HR, hazard ratio; CI, confidence interval; SPOP, speckle-type POZ domain protein.