SPOPL protein is expressed at diverse levels in MB tumors and normal human cerebellum histopathological sections, as examined by immunohistochemistry. Expression of SPOPL in normal human cerebellum was almost completely detectable. (A) Magnification, ×200. (B) Magnification, ×400. SPOPL expression in the primary lesion of MB tumors was highly detectable. (C) Magnification, ×200. (D) Magnification, ×400. Expression of SPOPL in the MB tumors was only marginally detectable. (E) Magnification, ×200. (F) Magnification, ×400. SPOPL, Speckle-type POZ protein-like; MB, medulloblastoma.