Table I.
IQGAP1 expression and localization in healthy colon and CRC tissues.
| Cell type | Healthy colon | CRC |
|---|---|---|
| Epithelial cells (Mucosae) | +++ | +++/− |
| lm, am, n, c | pm, lm, c, n | |
| Stromal cells (Mucosae) | − | ++/− |
| Tumor cells | − | +++/− |
| pm, c, n | ||
| Tumor associated stromal cells | − | ++/− |
| Immune cells | ? | +++ |
| Endothelial cells | ++ | ++ |
| n | n, c | |
| Smooth muscle cells | ++ | − |
| n | ||
| Neurons (Myenteric plexus) | ++ | − |
| Glial cells (Myenteric plexus) | ++ | − |
−, negative; ++, moderate; +++, high; ++/−, variable from moderate to absent; +++/−, variable from high to absent; ?, indeterminate staining; lm, lateral membrane; am, apical membrane; pm, plasma membrane; c, cytoplasm; n, nucleus or nuclear envelope.