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. 2017 Jul 8;14(3):2947–2953. doi: 10.3892/ol.2017.6542

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Copyright: © Feng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Metformin inhibited mammosphere growth via downregulating the expression of Rab27A. (A) Representative images of mammospheres treated with 1 mM and 5 mM metformin, respectively. (B) The mRNA expression levels of Rab27A were analyzed using reverse transcription-quantitative polymerase chain reaction following treatment of MDA-MB-231 cells with metformin. (C) Protein expression levels of Rab27A were analyzed via western blot analysis following treatment of MDA-MB-231 cells with metformin. (D) Rab27A increased the sensitivity of mammospheres to metformin. Error bars=standard deviation between triplicates. *P<0.05 vs. control.