Table 4.
Frequency of SP resistance-associated mutations in the dhfr and dhps genes of the asymptomatic P. falciparum isolates
| Gene | Codon | Genotype | Frequency (n = 40) |
|---|---|---|---|
| pfdhfr | 51 | Wild (N) | 12 (30) |
| Mixed (N + I) | 10 (25) | ||
| Mutant (I) | 18 (45) | ||
| Mutant or mixed genotype | 28 (70) | ||
| 59 | Wild (C) | 10 (25) | |
| Mixed (C + R) | 16 (40) | ||
| Mutant (R) | 14 (35) | ||
| Mutant or mixed genotype | 30 (75) | ||
| 108 | Wild (S) | 8 (20) | |
| Mixed (S + N) | 10 (25) | ||
| Mutant (N) | 22 (55) | ||
| Mutant or mixed genotype | 32 (80) | ||
| pfdhfr single | 59 | Mixed genotype | 2 (5) |
| mutants | 108 | Mutant or mixed genotype | 3 (7.5) |
| pfdhps | 437 | Wild (A) | 25 (62.5) |
| Mixed (A + G) | 12 (30) | ||
| Mutant (G) | 3 (7.5) | ||
| Mutant or mixed genotype | 15 (37.5) | ||
| 540 | Wild (K) | 31 (77.5) | |
| Mixed (K + E) | 7 (17.5) | ||
| Mutant (E) | 2 (5) | ||
| Mutant or mixed genotype | 9 (22.5) | ||
| pfdhps double | Mutant or mixed genotype | 6 (15) | |
| mutants | |||
Values are numbers with percentages in parentheses. n = Number of P. falciparum isolate DNA samples genotyped for dhfr and dhps mutations.