Table 3.
Sensitivity, specificity, predictive values, likelihood ratios, and OR for the optimal cutoff for the number of medications prescribed for predicting risk of PIM according to the STOPP and Beers 2012 criteria
| Cutoff ≥6 drugsa | PIM group, n/total (%) | Non-PIM group, n/total (%) | Sen, % (95% CI) | Spe, % (95% CI) | PPV, % (95% CI) | NPV, % (95% CI) | PLR (95% CI) | NLR (95% CI) | Adjusted OR (95% CI) | p |
|---|---|---|---|---|---|---|---|---|---|---|
| STOPP criteria | 74/94 (78.7) | 29/47 (61.7) | 79 (69–87) | 38 (25–54) | 72 (62–80) | 47 (31–64) | 1.3 (1.0–1.6) | 0.6 (0.3–0.9) | 2.1 (1.1–5.0) b | 0.034 |
| Beers 2012 criteria | 76/94 (80.9) | 27/47 (57.4) | 81 (71–88) | 43 (28–58) | 74 (64–82) | 53 (36–69) | 1.4 (1.1–1.8) | 0.5 (0.3–0.8) | 2.2 (1.3–6.6)c | 0.012 |
NLR = Negative likelihood ratio; PLR = positive likelihood ratio; Sen = sensitivity; Spe = specificity.
a
Optimal cutoff value estimated using the Youden index.
b
Adjusted for age, sex and severity of comorbidities.
b
Adjusted for age, sex, severity of comorbidities and history of psychiatric disorders.