Table 3.
Effect of vitamin D replacement therapy on renal function and glycemic parameters and vitamin D status
| Parameters | Patients, n | At baseline | After treatment | p valuea |
|---|---|---|---|---|
| Renal functionb | ||||
| Serum vitamin D, ng/mL | 383 | 18.1 (15.5) | 25.5 (19.1) | 0.001 |
| Serum creatinine, mg/dL | 368 | 0.8 (0.2) | 0.8 (0.2) | 0.054 |
| eGFR, mL/min/1.73 m2 | 368 | 92.3 (30.3) | 91.4 (30.4) | 0.001 |
| SUA, mg/dL | 72 | 4.8 (2.0) | 5.0 (1.5) | 0.470 |
| HbA1c, %b | 373 | 7.4 (2.7) | 6.7 (1.9) | 0.001 |
| Mean (95% CI) | 7.8 (7.6 – 8.0) | 7.1 (6.9– 7.2) | 0.001 | |
| Vitamin D status, n (%) | ||||
| Deficiency | 224 (58.5) | 140 (36.6) | 0.001 | |
| Insufficiency | 83 (21.7) | 101 (26.4) | ||
| Normal | 76 (19.8) | 142 (37.1) | ||
eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin A1c; SUA, serum uric acid; UACR, urine albumin-to-creatinine ratio.
a
Results of comparison to normal vitamin D group.
b
Median (IQR).