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. 2017 Aug 25;13:1788–1795. doi: 10.3762/bjoc.13.173

Scheme 2.

Scheme 2

Chemical and enzymatic esterification of erythro-1a with isopropenyl acetate (2a) in the ball mill. Reaction conditions: erythro-1a (50 mg, 0.15 mmol), 2a (0.60 mmol), CALB (30 mg of immobilized enzyme) or NaOH (12 mg, 0.30 mmol), 10 mL ZrO2 milling jar, 6 ZrO2 milling balls (5 mm in diameter).