Fig. 6.

Treatment with 2076A alleviates HFD-induced hyperglycemia, hyperinsulinemia, and insulin resistance. Mice were the same as described in Fig. 4. (A) Fasting blood glucose level. (B) Fasting serum insulin level. (C) Serum cholesterol level. (D) Serum triglyceride level. (E–G) GTT (E), ITT (F), and GSIS (G) test. The GTT, ITT, and GSIS results were also quantified as the area under the curve (AUC). WT, n = 4 for each group; FXR KO, n = 5 for each group. *P < 0.05; **P < 0.01, compared with the vehicle-treated group.