Table 2.
Association of MCP-1 with AKI
| Time point | Tertile (MCP-1 level in pg/ml) | AKI events (%) | Odds Ratio (95% CI)† | ||
|---|---|---|---|---|---|
| Unadjusted | Model 1 | Model 2 | |||
| AKI (0.3 mg/dl or >50% rise in serum creatinine, or requiring dialysis) | |||||
| Pre-op | Log | 1.76 (1.29, 2.42) | 1.36 (0.97, 1.90) | 1.27 (0.90, 1.79) | |
| T1 (12–147) | 95 (30%) | Referent | Referent | Referent | |
| T2 (147–196) | 93 (29%) | 1.01 (0.72, 1.42) | 1.10 (0.76, 1.59) | 1.16 (0.80, 1.68) | |
| T3 (196–1581) | 133 (42%) | 1.78 (1.28, 2.47) | 1.48 (1.04, 2.11) | 1.43 (1.00, 2.05) | |
| Post-op | Log | 1.50 (1.21, 1.85) | 1.25 (0.98, 1.58) | 1.62 (1.03, 2.56) | |
| T1 (40–359) | 91 (28%) | Referent | Referent | Referent | |
| T2 (359–600) | 114 (35%) | 1.41 (1.01, 1.96) | 1.27 (0.88, 1.82) | 0.87 (0.45, 1.69) | |
| T3 (600–1581) | 124 (38%) | 1.65 (1.18, 2.30) | 1.29 (0.89, 1.87) | 1.63 (0.83, 3.19) | |
| Severe AKI (>100% rise in serum creatinine or requiring dialysis) | |||||
| Pre-op | Log | 1.68 (0.86, 3.27) | 1.27 (0.59, 2.72) | 1.19 (0.55, 2.60) | |
| T1 (12–147) | 9 (3%) | Referent | Referent | Referent | |
| T2 (147–196) | 12 (4%) | 1.34 (0.56, 3.23) | 1.21 (0.49, 2.99) | 1.15 (0.46, 2.89) | |
| T3 (196–1581) | 20 (6%) | 2.31 (1.04, 5.16) | 1.62 (0.69, 3.77) | 1.48 (0.62, 3.54) | |
| Post-op | Log | 1.88 (1.18, 2.99) | 1.57 (0.96, 2.56) | 2.07 (0.85, 5.04) | |
| T1 (40–359) | 8 (3%) | Referent | Referent | Referent | |
| T2 (359–600) | 19 (6%) | 2.46 (1.06, 5.70) | 2.40 (1.02, 5.69) | 1.05 (0.23, 4.84) | |
| T3 (600–1581) | 18 (6%) | 2.32 (1.00, 5.42) | 1.88 (0.78, 4.53) | 2.36 (0.55, 10.03) | |
†
Logistic regression
For preoperative biomarkers:
Model 1: Adjusted for age, sex, race, non-elective surgery, diabetes, hypertension, center, heart failure, myocardial infarction, preoperative urine albumin to creatinine ratio, and type of surgery (CABG or valve vs. all others).
Model 2: Model 1 + preoperative eGFR
For postoperative biomarkers:
Model 1: Adjusted for age, sex, race, CPB>120 minutes, non-elective surgery, preoperative eGFR, diabetes, hypertension, center, heart failure, myocardial infarction, preoperative urine albumin to creatinine ratio, and type of surgery (CABG or valve vs. all others)
Model 2: Model 1 + change in serum creatinine from preoperative to peak + baseline MCP-1 level