Table 1.

Characteristics and Endpoint definitions of included randomized trials

Study	Year	Location	N	Study design	Primary endpoint	Mortality reported	Type of stent	MACCE definition	Follow up (years)
EXCEL [7]	2016	Multicenter	1905	RCT	death, MI, Stroke,	Yes	DES (EES)	death, MI, Stroke, IDR	3
NOBLE [8]	2016	Multicenter	1184	RCT	death, MI, Stroke, RR	Yes	DES (SES/BES)	death, MI, Stroke, RR	5
LE MANS [18]	2016	Multicenter	105	RCT	LVEF	Yes	DES/BMS	death, MI, Stroke, TVR	10
PRECOMBAT [17]	2015	Multicenter	600	RCT	death, MI, Stroke, IDR	Yes	DES (SES)	death, MI, Stroke, IDR	5
SYNTAX [16]	2014	Multicenter	705	RCT	death, MI, Stroke, RR	Yes	DES (PES)	death, MI, Stroke, RR	5

Abbreviations: MI myocardial infarction, IDR Ischemia driven revascularization, RR repeat revascularization, LVEF left ventricle ejection fraction, TVR target vessel revascularization, RCT randomized clinical trials (see Additional file 5)