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. 2017 Jul 21;190(1):54–67. doi: 10.1111/cei.13002

Figure 2.

Figure 2

Exacerbation of coronary arteritis by calcineurin inhibitors (CNIs) in CB‐17 severe combined immunodeficiency (SCID) mice. CB‐17 mice were administered 40 mg/kg of cyclosporin A (CsA), 2 mg/kg of tacrolimus (Tac) or a solvent control [10% dimethylsulphoxide (DMSO)] intraperitoneally with 100 μg of FK565 [per os (p.o.)] once daily for 5 consecutive days. A histological evaluation of coronary arteritis (a) induced by CsA or Tac and 100 μg of FK565 in CB‐17 SCID mice (scale bar, 100 μm). The numbers (b) and infiltration areas (c) of inflammatory cells are shown. The data are presented as the mean ± standard deviation (s.d.) (n = 3). *P < 0·05 (Dunnett's test). [Colour figure can be viewed at wileyonlinelibrary.com]