Figure 5.

B2 ameliorates cutaneous inflammation in a mouse model. (a,b) Mouse ears were treated topically with B2 and subsequently injected intradermally with phosphate‐buffered saline (PBS) as a vehicle or mouse interleukin (IL)‐23 every other day for 14 days (n = 6 mice/group). Ear swelling was evaluated 24 h after the final injection. Histology of mouse ear sections was assessed by haematoxylin and eosin (H&E) staining. Acanthosis (c) and dermal cellular infiltrates (d) of skin injected with PBS or B2 collected from mice injected with IL‐23. *P < 0·05 and **P < 0·001 versus either IL‐23‐induced group. Scale bar = 100 mm. [Colour figure can be viewed at wileyonlinelibrary.com]