Table 1.
Effects of a series of withanolide compounds isolated from Datura metel L. flowers on immune responses in mouse T cells using one‐way mixed lymphocyte reactions (MLRs)
| Compounds | Concentration (µM) | IC50 (µM) | |||
|---|---|---|---|---|---|
| 50 | 25 | 12.5 | 6.25 | ||
| B2 | 99·3 ± 3·0 | 93·1 ± 2·0 | 60·1 ± 3·4 | 32·1 ± 3·2 | 9·25 ± 1·2 |
| B4 | 97·4 ± 3·2 | 90·9 ± 3·0 | 51·9 ± 2·0 | 26·2 ± 2·0 | 10·55 ± 2·5 |
| G1 | 95·7 ± 3·4 | 70·3 ± 2·2 | 46·4 ± 5·0 | 7·1 ± 2·7 | 15·7 ± 2·3 |
| GB | 99·1 ± 4·4 | 63·3 ± 6·0 | 18·1 ± 2·1 | — | 19·41 ± 2·7 |
| G3 | 98·9 ± 3·1 | 78·7 ± 2·9 | 34·6 ± 5·7 | 7·5 ± 3·4 | 14·83 ± 1·9 |
| G4 | 67·6 ± 3·3 | 46·5 ± 6·0 | 26·1 ± 3·3 | 12·5 ± 2·5 | 27·6 ± 2·7 |
| G5 | 98·2 ± 3·5 | 76·3 ± 4·0 | 20·4 ± 4·4 | 6·8 ± 3·5 | 16·49 ± 2·1 |