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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Stroke. 2017 Aug 1;48(9):2353–2360. doi: 10.1161/STROKEAHA.117.017357

Table 3.

Relationship between the presence of infarcts overall and incident dementia

Overall infarcts Infarcts vs. no infarcts (n) Model 1 Model 2 Model 3 Model 4
Incident
dementia
(n=358)		 Without
dementia
(n=2254)		 Risk-ratio
(95%CI)		 Risk-ratio
(95%CI)		 Risk-ratio
(95%CI)		 Risk-ratio
(95%CI)
No prevalent & no incident 169 1388 Reference Reference Reference Reference
One or more prevalent & no incident 65 445 1.0 (0.8–1.3) 1.1 (0.8–1.4) 1.0 (0.8–1.4) 1.0 (0.7–1.3)
One or more incident & no prevalent 52 200 1.5 (1.2–2.00) 1.6 (1.2–2.1) 1.6 (1.2–2.1) 1.6 (1.2–2.1)
One or more prevalent & one or more incident 72 221 1.7 (1.3–2.2) 1.7 (1.3–2.2) 1.6 (1.2–2.1) 1.4 (1.1–1.9)

Values show number of persons with infarcts overall versus those without infarcts in groups of persons with and without incident dementia together with the risk-ratios of incident dementia by infarct group. Risk-ratios are with 95% confidence intervals (95%CI). Model 1: Adjusted for baseline age, sex, time interval between MRI scans. Model 2: Additionally adjusted for vascular risk-factors and education. Model 3: Additionally adjusted for symptomatic infarcts. Model 4: Additionally adjusted for brain microbleeds and white matter hyperintensity volume.