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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: J Clin Neurosci. 2016 Oct 18;35:109–116. doi: 10.1016/j.jocn.2016.09.017

Table 2.

Univariate and multivariable statistical analysis of the association between the COMT Val158Met polymorphism and a history of preexisting psychiatric disease or substance abuse with post-traumatic stress disorder (PTSD) at 6-months post-injury.

Predictor Odds ratio (OR) [95% CI] Predictor sig. (p) Nagelkerke pseudo-R2 Model sig. (p)
Univariate analysis
 COMT Met158 0.25 [0.09–0.69] 0.006 11.0% –
 Preexisting psychiatric disorder 6.85 [2.54–18.49] 6.3 × 10−5 22.6% –
 Substance abuse 3.44 [1.26–9.38] 0.016 8.6% –
Multivariable analysis
 COMT Met158 0.32 [0.11–0.97] 0.044 29.5% 8.1 × 10−5
 Preexisting psychiatric disorder 5.17 [1.80–14.89] 0.002 – –
 Substance abuse 1.88 [0.60–5.88] 0.281

OR >1 represents greater odds of having six-month PTSD. CI = Confidence Interval; COMT = Catechol-O-Methyltransferase; OR = Odds Ratio; PTSD = post-traumatic stress disorder.