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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: J Clin Neurosci. 2016 Oct 18;35:109–116. doi: 10.1016/j.jocn.2016.09.017

Table 3.

Univariate and multivariable statistical analysis of the association between the COMT Val158Met polymorphism and post-traumatic stress disorder (PTSD) with global functional outcome (GOSE) at six months post-injury.

Predictor Odds ratio (OR) [95% CI] Predictor sig.(p) Nagelkerke pseudo-R2 Model sig. (p)
Univariate analysis
 COMT Met158 2.87 (1.20–6.86) 0.018 5.9% –
 PTSD 0.08 [0.03–0.21] 3.62 × 10−7 30.6% –
 Age (y) 0.99 [0.97–1.02] 0.499 0.5% –
 No GCS deficit 2.55 [1.00–6.57] 0.051 3.9% –
Multivariable analysis
 COMT Met158 1.73 [0.69–4.35] 0.243 32.8% 9.06 × 10−7
 PTSD 0.09 [0.03–0.26] 5.0 × 10−6 – –
 Age (y) 1.00 [0.98–1.03] 0.723
 No GCS deficit 1.86 [0.69–5.01] 0.218

OR >1 represents greater odds of higher six-month functional outcome score on GOSE. COMT = Catechol-O-Methyltransferase; CI = Confidence Interval; GOSE = Glasgow Outcome Scale Extended; OR = Odds Ratio; PTSD = post-traumatic stress disorder.