NPs incite localized inflammatory response by day 7. Representative images for (A) Vehicle, (B) Blank NPs, (C) SDF-1 bolus, and (D) SDF-1 NPs at day 7 immunostained with Iba-1 demonstrated the prominent and robust inflammatory response local to injections (B and D). Red = Iba-1, Green = CXCR4, Blue = DAPI. Scale bar = 200 μm.