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. Author manuscript; available in PMC: 2017 Sep 7.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2015 Mar 5;35(5):1236–1245. doi: 10.1161/ATVBAHA.114.304864

Figure 5.

Figure 5

Hypoxia-induced pulmonary hypertension and right ventricular hypertrophy are abrogated in β platelet-derived growth factor receptor (βPDGFR)F3/F3 mice. A and B, Right ventricular systolic pressure (RVPsyst) and right ventricular hypertrophy, presented as the ratio of right ventricle (RV) to left ventricle (LV) plus septum (S) weight (RV/LV+S) in mice (genotypes: wild-type, βPDGFRF3/+, and βPDGFRF3/F3) subjected to normoxia (21% O2) or hypoxia (10% O2) for 3 weeks. C and D, Systolic and diastolic blood pressure (BP) in the various genotypes treated as in (A) and (B) as assessed via cannulation of the carotid artery. E, Heart rate of mice treated as in (A) and (B). n ≥ 6 in each group; *P<0.05, **P<0.01, ***P<0.001.