. Author manuscript; available in PMC: 2018 Mar 1.

Published in final edited form as: J Neurooncol. 2017 Jan 23;132(1):181–188. doi: 10.1007/s11060-016-2357-9

Table 2. Dose Expansion and DLT.

Dose	Arm 1	Arm 2	Arm 3
DL0 (2mg/kg)	0/3	0/3	0/3
DL1 (4mg/kg)	0/7^*	1/8^**	1/6
Dose expansion (4mg/kg)	0/11^*	1/9	2/9

DL : Dose level,

1 patient was replaced for serious adverse event before starting aflibercept,

^**

1 patient was replaced for incorrect dosing.