Table 3A. Grade 3 and 4 toxicities attributed to aflibercept and temozolomide for Arm 1.

Adverse Event	Aflibercept DL0	Aflibercept DL1	Temozolomide (DL0)	Temozolomide (DL1)
Abdominal pain	1
Alanine aminotransferase increase		1
Aspartate aminotransferase increase		1
Alkaline phosphatase increase		1
Bilirubin increase		2		1
Gamma glutamyl transferase increase		1
Arthralgia		1		1
Colonic perforation	1
Colitis				1
Dehydration				1
Fatigue	1		1
Headache		1
Hypertension		1
Hypokalemia		1
Hyponatremia				1
Seizure		3		3
Nausea			1
Lung infection			1
Peripheral nerve infection				1
Urinary tract infection				1
Vascular access complication	1	1
Leukopenia		1		1
Lymphopenia		3		4
Neutropenia		2		2
Thrombocytopenia		2		2
Investigations (other)				1