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| Adverse Event | Aflibercept DL0 | Aflibercept DL1 | Temozolomide (DL0) | Temozolomide (DL1) |
|---|---|---|---|---|
| Biliary anastomotic leak | 1 | |||
| Aspartate aminotransferase increase | 1 | |||
| Cholecystitis | 1 | 1 | ||
| Diarrhea | 1 | |||
| Fatigue | 1 | 1 | ||
| Dysphasia | 1 | |||
| Hypertension | 5 | 2 | ||
| Hyponatremia | 1 | 1 | ||
| Palmar-plantar erythrodysesthesia syndrome | 1 | |||
| Thromboembolic event | 1 | |||
| Leukopenia | 2 | 2 | ||
| Lymphopenia | 4 | 4 | ||
| Neutropenia | 2 | 1 | 2 | |
| Thrombocytopenia | 2 | 3 |
