Table 3C. Grade 3 and 4 toxicities attributed to aflibercept and temozolomide for Arm 3.
| Adverse Event | Aflibercept DL0 | Aflibercept DL1 | Temozolomide (DL0) | Temozolomide (DL1) |
|---|---|---|---|---|
| Aspartate aminotransferase increase | 1 | 1 | ||
| Acute kidney injury | 1 | |||
| Creatinine increase | 1 | |||
| Anorexia | 1 | 1 | ||
| Fatigue | 3 | 3 | ||
| Headache | 1 | 1 | ||
| Hypertension | 2 | |||
| Vagus nerve disorder | 1 | |||
| Pain in extremity | 1 | 1 | ||
| Palmar-plantar erythrodysesthesia syndrome | 2 | 2 | ||
| Thromboembolic event | 3 | |||
| Leukopenia | 2 | 3 | ||
| Lymphopenia | 1 | 4 | 1 | 7 |
| Neutropenia | 2 | 3 | ||
| Thrombocytopenia | 1 | 1 | ||
| Investigations (other) | 1 |