. Author manuscript; available in PMC: 2018 Mar 1.

Published in final edited form as: J Neurooncol. 2017 Jan 23;132(1):181–188. doi: 10.1007/s11060-016-2357-9

Table 5. Clinical Trial Battery (CTB) Test Change Scores from Baseline to Week 11 and Comparison with RTOG 0525.

	Mean (SD)	Median	Range	% Decline^*	% Decline RTOG 0525^**^[16]
CTB COMP (n=9)	-0.71 (1.70)	-0.40	-3.86, 2.11	44	29
*Learning and Memory*
HVLT-R TR (n=9)	-0.79 (1.13)	-0.23	-2.33, 0.53	44	28
HVLT-R DR (n=8)	-0.97 (1.65)	-1.66	-3.53, 1.29	63	22
HVLT-R R (n=9)	-0.78 (1.89)	0.0	-4.54, 1.82	33	22
*Processing Speed*
TMTA (n=9)	-0.13 (4.53)	-0.70	-4.73, 11.06	44	24
*Executive Function*
TMTB (n=9)	-1.84 (6.03)	-1.39	-16.64, 5.54	44	28
COWA (n=9)	0.34 (0.60)	0.54	-0.32, 1.25	0	12

Decline was defined by the reliable change index (RCI) for all CTB tests and as worsening in the CTB COMP z-score of ≥ 0.50

^**

Change from Baseline to Prior to Cycle 4 average across both arms