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. 2017 Jul 15;31(14):1456–1468. doi: 10.1101/gad.300244.117

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© 2017 Simón-Carrasco et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — Cic repressor activity is essential for mouse development. (A) Body weight of Cic^+/+, Cic^+/Δ2–6, and Cic^{Δ2–6/Δ2–6} embryos at E18.5. Data represent mean ± SD. Asterisks depict statistically significant differences. (*) P < 0.05; (***) P < 0.001, unpaired Student's t-test. (B) Representative images of Cic^+/+ (left) and Cic^{Δ2–6/Δ2–6} (middle) embryos at E18.5. (Right) Hematoxilin and eosin (H&E) staining of a whole Cic^{Δ2–6/Δ2–6} embryo section at E18.5. Bar, 2 mm. Arrowheads indicate omphaloceles. (C) H&E, Ki67, TTF-1, and SP-C immunohistochemistry (IHC) as well as periodic acid Schiff (PAS) staining in lung sections of Cic^+/+ and Cic^{Δ2–6/Δ2–6} embryos at E18.5. Bars: H&E, Ki67, TTF-1, and SP-C, 50 µm; PAS stainings, 25 µm. Inlays in PAS stainings represent magnifications.