Variables	Measures	T0 Pretest baseline before intervention	T1 Post-test after intervention	T2 Follow-up 1 3 months after intervention	T3 Follow-up 2 6 months after intervention	T4 Follow-up 3 12 months after intervention
Psychological variables
Anxiety and depression	HADS	X	X	X	X	X
Coping strategies	CSQ-R	X	X	X	X	X
QoL	A36Hemofilia-Qol	X	X	X	X	X
Illness perception	IPQ-R	X	X	X	X	X
Functional variables
Joint orthopaedic status	Pettersson Score and Gilbert Score	X		X		X
Physiological variables
Inflammatory biomarkers	Cytokines (IL-1β, IL-6, TNF-α, IL-10) and hs-CRP	X		X		X
WBC count		X		X		X

CSQ-R, Coping Strategies Questionnaire-Revised Form; HADS, Hospital Anxiety and Depression Scale; hs-CRP, high-sensitivity C-reactive protein; IL, interleukin; IPQ-R, Illness Perception Questionnaire; QoL, quality of life; TNF, tumour necrosis factor; WBC, white blood cell.