Table 2.
Association between antihypertensive medications and all-cause mortality according to ethnicity
Drug | Adjusted HR* (95% CI) | |||||
South Asian | Chinese | Other | ||||
HR | p Value | HR | p Value | HR | p Value | |
ACEi | 0.91 (0.71 to 1.17) | 0.47 | 0.84 (0.69 to 1.03) | 0.09 | 0.88 (0.84 to 0.91) | <0.0001 |
ARB | 0.88 (0.63 to 1.25) | 0.48 | 0.64 (0.50 to 0.82) | 0.0004 | 0.69 (0.64 to 0.74) | <0.0001 |
CCB | 1.25 (0.93 to 1.68) | 0.14 | 0.94 (0.77 to 1.15) | 0.56 | 1.00 (0.94 to 1.05) | 0.89 |
Diuretic | 0.83 (0.61 to 1.12) | 0.22 | 0.77 (0.62 to 0.96) | 0.02 | 0.66 (0.63 to 0.69) | <0.0001 |
*Cox proportional hazards models were weighted using a propensity score model by the IPTW method adjusted for age, sex, SES, Charlson comorbidities and use of other medications (insulin, ACEi, ARB, beta-blockers, CCB, diuretics and statins) at baseline, defined as a prescription within 1 month before or after diagnosis.
ACEi, ACE inhibitor; ARB, angiotensin receptor blocker; CCB, calcium channel blocker; IPTW, inverse probability of treatment weighted; SES, socioeconomic status.