Figure 1.

SC Inhibited HNSCC Cell Growth In Vitro

(A) The chemical structure of SC. (B) UM-SCC-22B and UM-SCC-47 cells were treated with increased concentrations of SC for 48 hr. Cell viabilities were evaluated by the CKK-8 assay. (C) Cells were treated with different concentrations of SC for 24 hr and fixed in 95% ethanol and stained with a 4 g/L crystal violet solution. The invaded cells were counted in five randomly selected areas under a 100 × microscope field. Scale bars, 100 μm. (D) The cells were treated as previously, and the wound healing assay was performed to measure the cell migration abilities. Scale bars, 50 μm. Data are shown as mean ± SD of three independent experiments. *p < 0.05, **p < 0.01, and ***p < 0.001 compared with DMSO control.