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. Author manuscript; available in PMC: 2017 Sep 7.
Published in final edited form as: ACS Chem Neurosci. 2015 Apr 30;6(6):920–926. doi: 10.1021/acschemneuro.5b00077

Table 3.

Dopamine Release from Striatal Synaptosomes Stimulated by (+)- and (−)-PHTa

(+) PHT res α4β2 (+) PHT sens α6β2 (+) PHT α4β2 in α5KO* (+) PHT α6β2 in α5KO (−) PHT res α4β2 (−) PHT sens α6β2 (−) PHT α4β2 in α5KO* (−) PHT α6β2 in α5KO
EC50 0.4 μM 0.13 μM 2 μM 0.20 μM 4 μM 4.5 μM 0.7 μM 2 μM
sem ±0.2 μM ±0.04 μM ±3 μM ±0.06 μM ±3 μM ±0.6 μM ±0.8 μM ±2 μM
maxb (% nic) 33% 94% 13% 125% 17% 109% 10% 96%
sem ±5% ±18% ±4% ±8% ±3% ±25% ±2% ±12%
binding Kic 1.7 nM 28 nM 35 nM 629 nM
sem ±0.2 nM ±3.1 nM ±1.8 nM ±19 nM
a

EC50 from n = 3–4 experiments; DA release from mouse striatal synaptosomes; res = αCtxMII resistant (response); sens = αCtxMII sensitive (response).

b

Max (% nic) from n = 7–8 experiments; comparison of 10 μM nic response to 10 μM (+) PHT or 100 μM (−) PHT.

c

Binding Ki values from inhibition of [125I]epibatidine binding to membranes prepared from mouse cortex (α4β2 sites only) or membranes prepared from striatum and olfactory tubercle from α4KO mice (α6β2 sites only).