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. 2017 Sep 7;12(9):e0180413. doi: 10.1371/journal.pone.0180413

Fig 6. The effect of LAG-3 silencing on cytokine production in co-cultures supplemented with CD4+ T-cells isolated the lung of Mtb-infected rhesus macaques.

Fig 6

(A) Concentrations of IFN-γ, (B) IL-6 and (C) CXCL11 in Mtb-infected macrophage culture, untreated co-culture, and LAG-3 silenced co-culture at 48h post-infection. (D) The presence of MIF in Mtb-infected macrophage culture, untreated co-culture, and LAG-3 silenced co-culture at 24h post-infection. All samples were measured in pg/ml. Statistical significance was determined using a one-way ANOVA in Prism 6, using multiple comparisons to compare each mean, with the Tukey multiple comparison test; the mean and SEM are represented by horizontal bars. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.