Table 1. Log2 average fold change values of gene expression for select immune function genes amongst biological replicate samples from Mtb-infected macrophages (24h) as well as the two co-culture sets (Mtb-infected macrophages (24h) + infected lung CD4+ T-cells; Mtb-infected macrophages (24h) + infected lung CD4+ T-cells where LAG-3 expression was silenced by RNAi).
| Gene (Symbol) | Macs+Mtb | Macs+Mtb+ILU CD4 | Macs+Mtb+ILU CD4 (LAG3 siRNA) |
|---|---|---|---|
| CCL2 | 1.53 | 0.15 | -2.37 |
| CCL3 | 1.24 | 0.97 | 4.29 |
| CCL5 | 0.74 | 0.15 | -2.37 |
| CCL15 | 0.98 | 0.84 | -2.06 |
| CCL18 | 1.59 | -0.79 | -0.86 |
| CCR5 | 0.61 | -0.18 | 0.86 |
| CCR7 | 1.08 | -0.30 | 4.24 |
| CXCL2 | 1.69 | 1.42 | 4.57 |
| CXCL6 | 0 | 0 | 5.87 |
| CXCL9 | 1.07 | 0.87 | -3.94 |
| CXCL13 | 2.25 | 3.25 | 3.10 |
| CXCL14 | 2.05 | 0 | 1.12 |
| CXCR6 | 1.20 | 0.97 | 1.33 |
| GADD45A | 2.90 | 0.68 | 3.18 |
| IL1R2 | 1.34 | 1.36 | 0.42 |
| IL1RL1LG | 0.65 | 0.10 | 0.65 |
| IL12RB2 | 0.97 | 0.86 | 2.22 |
| IL17RC | 0.60 | -0.08 | 0.18 |
| IL21R | 0.92 | 0.65 | 2.15 |
| IL23A | 1.95 | 0.53 | 2.15 |
| IL27RA | 0.95 | 0.71 | -0.80 |
| IL4R | 0.63 | 0.15 | 0.89 |
| NFIL3 | 1.48 | 0.26 | 1.68 |
| PTGS2 | 1.66 | 1.40 | 5.36 |