Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Normal and abnormal adrenal steroidogenesis in the zona fasciculata. The normal pathway is shown on the left. Loss of function mutations in CYP21A2 (steroid 21-hydroxylase) lead to congenital adrenal hyperplasia (CAH; right), resulting in a massive increase in 17-hydroxyprogesterone. This 17-hydroxyprogesterone and upstream precursors are metabolized to androgens, probably via several distinct pathways.
