Figure 1.

Downregulated Expression Level of miR-491 in Serum Was Correlated with OS Progression

(A) The level of serum miR-491 was significantly decreased in OS patients (n = 102) compared with healthy control subjects (n = 20). (B) The level of serum miR-491 was significantly decreased in OS patients with metastasis (no metastasis) (n = 36) compared with patients with no metastasis (metastasis) (n = 66). (C) The level of serum miR-491 was significantly decreased in OS patients with poor chemoresponse (PR) (n = 19) compared with those with a good chemoresponse (GR) (n = 83). The level of miR-491 in serum was measured by qRT-PCR. (D) Kaplan-Meier analysis of overall survival rate for patients with OS with low and high serum miR-491 levels. *p < 0.05; **p < 0.01; ***p < 0.001.