Table 1. In vitro activity of miltefosine against S. mansoni adult worms.

Group	Dose μg/ml (μM)	Hours of incubation	Number	UncoupledWorms	Dead	Reduced activity a		Tegumental changes b
						+	++	+	++
Control		96	10	0	0	0	0	0	0
Praziquantel	2 (06.4)	24	10	0	05	0	5	0	0
	4 (12.8)	24	10	0	09	0	1	8	0
	6 (19.2)	24	10	1	10	0	0	3	7
	8 (25.6)	24	10	1	10	0	0	5	5
	10 (32.0)	24	10	1	10	0	0	6	4
Miltefosine	5 (12.5)	24	10	3	0	0	0	0	0
		48	10	7	0	0	0	0	0
		72	10	10	0	3	2	2	1
		96	10	10	0	5	5	5	2
	10 (25.0)	24	10	7	0	1	0	0	0
		48	10	8	2	1	1	2	2
		72	10	10	4	3	1	2	5
		96	10	10	7	3	0	3	7
	20 (50.0)	24	10	10	2	1	2	1	2
		48	10	10	4	2	6	3	5
		72	10	10	10	0	0	3	7
	40 (100.0)	24	10	10	4	3	2	6	4
		48	10	10	10	0	0	2	8

^a Dead worms were excluded. +, Slight. ++, Significant.

^b S1 Fig.