Table 1. In vitro activity of miltefosine against S. mansoni adult worms.
Group | Dose μg/ml (μM) | Hours of incubation | Number | UncoupledWorms | Dead | Reduced activity a | Tegumental changes b | ||
---|---|---|---|---|---|---|---|---|---|
+ | ++ | + | ++ | ||||||
Control | 96 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | |
Praziquantel | 2 (06.4) | 24 | 10 | 0 | 05 | 0 | 5 | 0 | 0 |
4 (12.8) | 24 | 10 | 0 | 09 | 0 | 1 | 8 | 0 | |
6 (19.2) | 24 | 10 | 1 | 10 | 0 | 0 | 3 | 7 | |
8 (25.6) | 24 | 10 | 1 | 10 | 0 | 0 | 5 | 5 | |
10 (32.0) | 24 | 10 | 1 | 10 | 0 | 0 | 6 | 4 | |
Miltefosine | 5 (12.5) | 24 | 10 | 3 | 0 | 0 | 0 | 0 | 0 |
48 | 10 | 7 | 0 | 0 | 0 | 0 | 0 | ||
72 | 10 | 10 | 0 | 3 | 2 | 2 | 1 | ||
96 | 10 | 10 | 0 | 5 | 5 | 5 | 2 | ||
10 (25.0) | 24 | 10 | 7 | 0 | 1 | 0 | 0 | 0 | |
48 | 10 | 8 | 2 | 1 | 1 | 2 | 2 | ||
72 | 10 | 10 | 4 | 3 | 1 | 2 | 5 | ||
96 | 10 | 10 | 7 | 3 | 0 | 3 | 7 | ||
20 (50.0) | 24 | 10 | 10 | 2 | 1 | 2 | 1 | 2 | |
48 | 10 | 10 | 4 | 2 | 6 | 3 | 5 | ||
72 | 10 | 10 | 10 | 0 | 0 | 3 | 7 | ||
40 (100.0) | 24 | 10 | 10 | 4 | 3 | 2 | 6 | 4 | |
48 | 10 | 10 | 10 | 0 | 0 | 2 | 8 |
a Dead worms were excluded. +, Slight. ++, Significant.
b S1 Fig.