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Represents a fMRI cross-over study in five abstinent heroin addicts receiving either placebo or KB220z (Synaptose) one–hour prior to testing. What is noteworthy is that following the KB220Z, there was BOLD activation in the NAc and an attenuation of high BOLD activation in the putamen. This illustration suggests a balancing of dopamine function in the brain at the reward site [Blum et al. 2012 – with permission].
