Table 1.
Drug loading, encapsulation efficiency, particle sizes and surface charges of SN-NPM.
| D/T ratioa | Encapsulation Efficiency (%)b | Drug content (%)c | Mean size/nm (PDI)d | Zeta potential (mV)d |
|---|---|---|---|---|
| 1/10 | 63.21±10.23 | 5.45 | 68.23±10.11 (0.412) | −7.34±0.55 |
| 1/20 | 85.12±6.53 | 4.05 | 23.21±8.23 (0.198) | −7.53±0.35 |
| 1/30 | 80.14±5.29 | 2.58 | 19.34±7.98 (0.201) | −7.77±0.17 |
a
D/T ratio=weight of SN-38/weight of telodendrimer.
b
Encapsulation efficiency (%)= [(Drug added - Free “unencapsulated drug”)/Drug added] *100
c
Drug content (%)= [Encapsulated Drug/weight of whole nanoparticle] * 100
d
Determined by dynamic light scattering (DLS)