Table 1.

Summary of the efficacy of viruses tested

Viral type	Serotype	Source	Promoter	Estimated transfection rate	Level of transfection (per cell)	Degree of spread	Neuronal specificity	Other notes
AAV	1	U.Penn	CMV	+++	++	+++	+++	Lesions at injection site
AAV	5	U.Penn	CMV	++	++	+++	+++	Showed tropism against transfecting area X
AAV	S	U.Penn	CMV	+	++	+	+++	Lesions at injection site
AAV	Rh/10	U.Penn	CMV	+	++	+	+++	Lesions at injection site
AAV	1	U.Penn	CBA	+++	+++	++	+++	Retrogradley transfected afferents
AAV	1	MIT/Virovek	CMV	+++	+++	++	+++
AAV	2	MIT/Virovek	CMV	++	+++	+	+++
AAV	5	MIT/Virovek	CMV	+++	+++	++	+++
AAV	8	MIT/Virovek	CMV	++	+++	++	+++
AAV	9	MIT/Virovek	CMV	++	+++	++	+++
Lentivirus	n/a	UCLA viral core	Synapsin 1	+	+	+	+++
Lentivirus	n/a	UCLA viral core	CMV	+	+++	+	+++
Lentivirus	n/a	UCLA viral core	PGK	+	+++	+	+	Caused lesion; infected non neuronal cell types
HSV	ST-HSV	MIT/Virovek	CMV	++	+++	++	+++	Requires dilution to avoid toxicity and retrograde transfection

Estimated transfection rate: + = <5%, ++ = 5–20%, +++ = >20%

Level of transfection per cell: + = not visible without IHC, ++ = visible but greatly enhanced by IHC, +++ = easily visible, not enhanced by IHC

Degree of spread: + = transfects an area much smaller than Area X, ++ = transfects an area much comparable in volume Area X, ++ + = transfects an area much greater than Area X

Neuronal specificity: + = transfects non-neuronal cell types exclusively, ++ = transfects neuronal and non-neuronal cell types, +++ = transfects neuron exclusively