. Author manuscript; available in PMC: 2019 Jan 1.

Published in final edited form as: Stat Methods Med Res. 2016 Jun 29;27(1):286–297. doi: 10.1177/0962280215627335

Table 2.

Variable importance measure (VIM; equation (1)) results based on cTMLE.

Characteristic	VIM (95% CI)
History of hepatic disease	−0.176 (−0.215; −0.136)^a
History of psychiatric disease	−0.103 (−0.156; −0.050)^a
Prior TBI	−0.037 (−0.078; 0.003)
Prior treatment with anticoagulants	0.024 (−0.024; 0.072)
Employment status at time of TBI (inactive vs. active)	−0.066 (−0.113; −0.019)^a
Marital Status at time of TBI (Married/living together vs. alone)	0.040 (−0.005; 0.084)
Hypotension (SBP < 90 mmHg)	−0.062 (−0.131; 0.070)
Tachycardia (HR > 100 bpm)	−0.045 (−0.083; −0.006)^a
Tachypnea (RR > 18 cpm)	−0.020 (−0.069; 0.028)
Hypoxia (SpO₂ < 94%)	0.010 (−0.018; 0.037)
GCS (<15 vs. 15)	−0.017 (−0.065; 0.031)
Positive drug screening	−0.009 (−0.085; 0.067)
Rotterdam classification (>2 vs. ≤2)	−0.081 (−0.127; −0.036)^a
Marshall classification (>1 vs. 1)	−0.107 (−0.153; −0.062) ^a
ANKK1 polymorphism: T/T vs. others	−0.467 (−0.879; −0.056)^a
ApoE polymorphism: E2/E4, E3/E4, E4/E4 vs. others	0.001 (−0.307; 0.308)

Note: The estimates are adjusted for all measures confoundings and obtained using collaborative targeted maximum likelihood estimation; 95% CI: 95% confidence intervals; Apo E: Apolipoprotein E; ENT: ear, nose, throat.

Statistical significance (p<0.05).