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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: J Viral Hepat. 2017 May 11;24(10):865–876. doi: 10.1111/jvh.12714

Fig. 2.

Fig. 2

Higher levels of constitutive STAT-1 phosphorylation and lower levels of in vitro IFN-α-induced direct cytotoxicity against K562 target cells in HIV/HCV co-infected subjects when compared to HCV mono-infected subjects. (A) Gating approach for phosphorylated (p)-STAT-1 on NK cell subsets [(isotype (red line), p-STAT-1 (blue line)]; (B) Constitutive MFI of p-STAT-1 on Lin3−CD56+CD16+, and CD3+CD14+ cells in HCV mono-infected and HIV/HCV co-infected subjects; (C) In vitro IFN-α-induced area under the curve (AUC) - constitutive AUC for effector:target (E:T) ratios of 50:1, 25:1, 12.5:1 and 6.25:1 in HCV mono-infected and HIV/HCV co-infected subjects. Data in panels (B) and (C) are shown as inter-quartile box plots with median and outliers for each group, and significant (<0.1) P values.