. Author manuscript; available in PMC: 2018 Oct 1.

Published in final edited form as: J Viral Hepat. 2017 May 11;24(10):865–876. doi: 10.1111/jvh.12714

Table 3.

Linear models using HCV vl (log10 copies/ml) and patients group as predictors of immune variables

Response	Terms ▸	HCV vl		Group^*

	Model ▾	Estimate	p	Estimate	p
Log10 MFI of CD38 on CD3⁺CD8⁺	1	−0.04	ns^ᵼ	−0.14	<0.0001
CD4⁺FoxP3⁺CD25⁺ %	1	−0.008	ns	0.14	0.0002
MFI of PD1 on CD3⁺CD8⁺	1	−1.99	ns	−3.85	ns
MFI of CTLA-4 on CD3⁺CD8⁺	1	2.83	ns	−11.48	0.04
MFI of BTLA on CD3⁺CD8⁺	1	−11.22	ns	−23.75	ns
MFI of CD160 on CD3⁺CD8⁺	1	0.36	ns	−8.86	<0.0001
MFI of CD69 on Lin3⁻CD56^dimCD16⁺	1	−1.65	ns	−2.78	0.04
MFI of CD81 on Lin3⁻CD56^dimCD16⁺	1	590.17	0.02	−98.78	ns
MFI of IFN-αR on Lin3⁻CD56^dimCD16⁺	1	−5.03	ns	39.33	0.01
Constitutive MFI of p-STAT-1 on Lin3⁻CD56⁺CD16⁺	1	−4.18	ns	−5.92	0.002
AUC IFNα-induced - AUC constitutive	1	26.11	ns	58.39	0.02
Log10 (IFNα-induced - constitutive) Lin3⁻CD56^dimCD16⁺IFN-γ⁺ % of Lin3⁻CD56^dimCD16⁺	1	−0.07	ns	0.11	ns
Log10 (IFN-α-induced - constitutive) Lin3⁻CD56^brightIFN-γ⁺ % of Lin3⁻CD56^bright	1	0.06	ns	−0.03	ns

Response	Terms ▸	HCV vl		Group		HCV vl: Group
Response	Model ▾	Estimate	p	Estimate	p	Estimate	p
MFI of CD69 on Lin3⁻CD56^dimCD16⁺	2	−2.04	ns	−2.7	ns	−3.93	0.03
Constitutive MFI of p-STAT-1 on Lin3⁻CD56⁺CD16⁺	2	−3.64	ns	−6.01	0.001	4.78	0.04
Log10 (IFNα-induced - constitutive) Lin3⁻CD56^dimCD16⁺IFN-γ⁺ % of Lin3⁻CD56^dimCD16⁺	2	−0.03	ns	0.1	ns	0.21	0.008

Group: HCV mono-infected, HIV/HCV co-infected.

^ᵼ

ns: non-significant