Table 1. Baseline characteristics of patients with unfavourable cytogenetic markers (CK and/or HR-FISH) at diagnosis.
| Patients characteristics | CK and non-HR-FISH (N = 42) | non-CK and HR-FISH (N = 113) | CK and HR-FISH (N = 57) | P-value |
|---|---|---|---|---|
| Median age at diagnosis (range) | 73 (46–87) | 67 (27–90) | 69 (45–88) | 0.322 |
| Male | 31 (73.9%) | 78 (69.0%) | 35 (61.4%) | 0.284 |
| Diagnosis | ||||
| MBL | 10 (23.8%) | 13 (11.5) | 4 (7.0%) | 0.039 |
| CLL | 32 (76.2%) | 100 (88.5%) | 53 (93.0%) | |
| Advanced Binet stage * | 9/42 (21.4%) | 33/109 (30.3%) | 11/56 (19.6%) | 0.262 |
| Lymphadenopathy | 16/42 (38.1%) | 56/110 (50.1%) | 28/55 (50.9%) | 0.323 |
| Splenomegaly | 3/40 (7.5%) | 15/109 (13.8%) | 8/53 (15.1%) | 0.512 |
| Hepatomegaly | 2/42 (4.8%) | 11/112 (9.8%) | 2/56 (3.6%) | 0.266 |
| Absolute white blood cell count (x109/L) | 16 (6–164) | 17 (4–168) | 21 (5–89) | 0.122 |
| Absolut lymphocyte count (x109/L) | 11 (2–105) | 11 (1–155) | 14 (2–82) | 0.091 |
| Hemoglobin (g/dL) | 14 (9–17) | 14 (6–18) | 14 (8–17) | 0.219 |
| Platelets (x109/L) | 190 (42–473) | 191 (10–413) | 173 (34–331) | 0.470 |
| Lactate dehydrogenase (IU/L) | 332 (160–1279) | 340 (139–1094) | 383 (156–1082) | 0.237 |
| Beta-2 Microglobulin (mg/L) | 2.4 (1.0–10.0) | 2.2 (1.0–13.4) | 2.6 (1.1–8.4) | 0.305 |
| ZAP-70 positive** | 7/20 (35.0%) | 17/62 (27.4%) | 16/31 (51.6%) | 0.071 |
| CD38 positive* | 11/31 (35.5%) | 33/96 (34.4%) | 14/42 (33.3%) | 0.982 |
| Unmutated IGHV | 1/5 (20.0%) | 2/2 (100%) | 13/14 (92.9%) | 0.003 |
| FISH | ||||
| 13q deletion | 16/42 (38.1%) | 54/110 (49.1%) | 34/55 (61.8%) | 0.064 |
| Trisomy 12 | 24/42 (57.1%) | 15/109 (13.8%) | 7/54 (13.02%) | < 0.001 |
| 11q deletion (ATM) | – | 68/113 (60.2%) | 25/57 (43.9%) | N.A. |
| 17p deletion (TP53) | – | 50/113 (44.2%) | 40/57 (70.2%) | N.A. |
Values are given as median (range) or number (%). Hemoglobin is expressed as mean (range). N.A. Not applicable.
*Binet stage was not available in five patients (information regarding physical examination and/or analytical parameters not provided).
**Positivity was considered when ZAP-70 > 20% and CD38 > 30%.