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. 2017 Apr 13;8(33):54478–54496. doi: 10.18632/oncotarget.17091

Figure 4. Short exposure to acidosis induces the release of inflammatory and nociceptive mediators in mesenchymal stromal cells of the BM microenvironment (deep sequencing of MSCs).

Figure 4

(A) Heat map representation of the fold increase, by deep-sequencing analysis, of the mRNA levels of inflammatory and nociceptive mediators of normal stromal cells (4 lots of BM-MSCs) after short-term acidosis (pH 6.5) compared to physiological medium (pH 7.4). Colors on the heat map indicate the log2 ratios of expression (representing normalized read counts). Red, upregulation; green, downregulation; (B) Short-term acidosis activates inflammatory and nociceptive mediators in normal mesenchymal cells. Graphical representation of transcriptional fold increases after short-term acidosis (24 hrs at pH 6.5) of inflammatory and nociceptive mediators genes, in respect to physiological medium (pH 7.4), in normal stromal cells as revealed by deep-sequencing analysis. Mean ± SE (N = 4 lots of BM-MSCs). *p < 0.05.