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. 2017 Apr 13;8(33):54478–54496. doi: 10.18632/oncotarget.17091

Figure 6. Short-term acidosis activates the expression of inflammatory mediators in BM-associated mesenchymal cells.

Figure 6

Graphical representation of mRNA expression over the time, starting from the acidosis exposure (medium at pH 6.8), of IL6 and IL8 (A) and of NF-κB transcription factors (B) in normal stromal cells, as revealed by Q-RT-PCR analysis. Mean ± SE (for MSC and HOB, N = 3 different lots, and for each lot, N =2 biological replicates, and N = 2 technical replicates; for CAF N = 1 lot, N = 2 biological replicates, N = 2 technical replicates). ***p<0.001, **p<0.01, and *p<0.05 versus the expression of the specified gene at the timing immediately before medium change with acidic medium in the same cells.