Table 4. Associations between CXCL12 SNPs and CAD.
| SNP | Model | Genotype | control | case | Crude analysis | adjusted by age and gender | ||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | |||||
| rs266089 | Codominant | G/G | 487 (71.2%) | 391 (65.5%) | 1 | 0.086 | 1 | 0.18 |
| G/A | 175 (25.6%) | 185 (31%) | 1.32 (1.03-1.68) | 1.31(0.97-1.75) | ||||
| A/A | 22 (3.2%) | 21 (3.5%) | 1.19 (0.64-2.19) | 0.91(0.43-1.94) | ||||
| Dominant | G/G | 487 (71.2%) | 391 (65.5%) | 1 | 0.028 | 1 | 0.11 | |
| G/A-A/A | 197 (28.8%) | 206 (34.5%) | 1.30 (1.03-1.65) | 1.26(0.95-1.67) | ||||
| Recessive | G/G-G/A | 662 (96.8%) | 576 (96.5%) | 1 | 0.77 | 1 | 0.65 | |
| A/A | 22 (3.2%) | 21 (3.5%) | 1.10 (0.60-2.02) | 0.84(0.40-1.78) | ||||
| Log-additive | --- | --- | --- | 1.23 (1.00-1.50) | 0.048 | 1.17(0.91-1.49) | 0.22 | |
| rs10793538 | Codominant | A/A | 594 (87.2%) | 544 (91.1%) | 1 | 0.06 | 1 | 0.61 |
| T/A | 81 (11.9%) | 51 (8.5%) | 0.69 (0.48-0.99) | 0.91(0.58-1.41) | ||||
| T/T | 6 (0.9%) | 2 (0.3%) | 0.36 (0.07-1.81) | 0.40(0.05-3.21) | ||||
| Dominant | A/A | 594 (87.2%) | 544 (91.1%) | 1 | 0.025 | 1 | 0.54 | |
| T/A-T/T | 87 (12.8%) | 53 (8.9%) | 0.67 (0.46-0.95) | 0.87(0.57-1.35) | ||||
| Recessive | A/A-T/A | 675 (99.1%) | 595 (99.7%) | 1 | 0.2 | 1 | 0.37 | |
| T/T | 6 (0.9%) | 2 (0.3%) | 0.38 (0.08-1.88) | 0.40(0.05-3.25) | ||||
| Log-additive | --- | --- | --- | 0.67 (0.48-0.94) | 0.018 | 0.86(0.57-1.28) | 0.45 | |
p <0.05, statistical significance.