Table 6. The relationship between CXCL12 genetic polymorphism and CAD was analyzed according to the age stratification.
| SNP | Model | Genotype | control | case | Crude analysis | adjusted by age and gender | |||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | ||||||
| <55 | rs197452 | Codominant | C/C | 393 (78.9%) | 141 (85.5%) | 1 | 0.073 | 1 | 0.081 |
| C/T | 101 (20.3%) | 24 (14.6%) | 0.66 (0.41-1.08) | 0.68 (0.42-1.11) | |||||
| T/T | 4 (0.8%) | 0 (0%) | 0.00 (0.00-NA) | 0.00 (0.00-NA) | |||||
| Dominant | C/C | 393 (78.9%) | 141 (85.5%) | 1 | 0.06 | 1 | 0.077 | ||
| C/T-T/T | 105 (21.1%) | 24 (14.6%) | 0.64 (0.39-1.03) | 0.65 (0.40-1.06) | |||||
| Recessive | C/C-C/T | 494 (99.2%) | 165 (100%) | 1 | 0.13 | 1 | 0.11 | ||
| T/T | 4 (0.8%) | 0 (0%) | 0.00 (0.00-NA) | 0.00 (0.00-NA) | |||||
| Log-additive | --- | --- | --- | 0.63 (0.39-1.00) | 0.042 | 0.64 (0.40-1.02) | 0.053 | ||
| ≥55 | rs197452 | Codominant | C/C | 141 (75.4%) | 328 (75.9%) | 1 | 0.97 | 1 | 0.96 |
| C/T | 42 (22.5%) | 94 (21.8%) | 0.96 (0.64-1.46) | 0.95 (0.63-1.44) | |||||
| T/T | 4 (2.1%) | 10 (2.3%) | 1.07 (0.33-3.48) | 1.09 (0.33-3.53) | |||||
| Dominant | C/C | 141 (75.4%) | 328 (75.9%) | 1 | 0.89 | 1 | 0.86 | ||
| C/T-T/T | 46 (24.6%) | 104 (24.1%) | 0.97 (0.65-1.45) | 0.97 (0.65-1.44) | |||||
| Recessive | C/C-C/T | 183 (97.9%) | 422 (97.7%) | 1 | 0.89 | 1 | 0.88 | ||
| T/T | 4 (2.1%) | 10 (2.3%) | 1.08 (0.34-3.50) | 1.10 (0.34-3.55) | |||||
| Log-additive | --- | --- | --- | 0.99 (0.69-1.40) | 0.94 | 0.98 (0.69-1.39) | 0.92 | ||
p <0.05, statistical significance.