Table 2. Univariate and multivariate analysis of factors related to recurrence in breast cancer patients.

Variables				ALU			LINE1
	univariate analysis			multivariate analysis			multivariate analysis
	P value	OR	95%CI	P value	OR	95%CI	P value	OR	95%CI
LINE1 cfDI	8.45E-04	3.96	(1.77-8.88)				0.019	3.74	(1.24-11.27)
ALU cfDI	5.63E-04	4.15	(1.85-9.31)	0.020	3.69	(1.23-11.02)
Age	0.58	1.01	(0.98-1.04)	0.65	0.99	(0.94-1.04)	0.67	0.99	(0.94-1.04)
Histotype	0.46	0.84	(0.54-1.32)	0.24	0.68	(0.35-1.23)	0.25	0.67	(0.34-1.32)
Grading	0.059	0.63	(0.39-1.02)	0.47	0.70	(0.27-1.84)	0.49	0.72	(0.29-1.80)
Focal	0.70	1.20	(0.49-2.94)	0.080	3.52	(0.86-14.37)	0.042	4.32	(1.06-17.68)
Tumor Size	7.21E-3	0.49	(0.29-0.83)	0.084	0.38	(0.13-1.14)	0.082	0.42	(0.16-1.12)
Nodus Stages	0.039	0.47	(0.23-0.96)	0.11	0.38	(0.12-1.24)	0.063	0.32	(0.099-1.06)
ER	6.15E-03	3.13	(1.38-7.08)	0.056	6.38	(0.95-42.71)	0.078	5.28	(0.83-33.71)
PR	0.013	1.83	(0.84-3.99)	0.25	0.35	(0.060-2.07)	0.28	0.39	(0.073-2.12)
HER2	0.69	1.26	(0.41-3.90)	0.44	2.50	(0.25-24.92)	0.38	2.88	(0.28-29.89)
p53	0.53	1.01	(0.99-1.02)	0.044	1.02	(1.00-1.05)	0.097	1.02	(1.00-1.04)
Ki67	0.066	0.98	(0.97-1.00)	0.22	0.98	(0.96-1.01)	0.13	0.98	(0.95-1.01)
Operation	0.76	0.90	(0.44-1.84)	0.36	0.56	(0.16-1.96)	0.35	0.55	(0.16-1.92)
Radio_therapy	0.54	1.34	(0.53-3.36)	0.32	2.23	(0.45-10.99)	0.28	2.33	(0.50-10.84)
Chemo_therapy	0.068	0.47	(0.21-1.06)	0.13	0.37	(0.099-1.34)	0.24	0.46	(0.124-1.69)

Statistically significant P < 0.05 in the univariate and multivariate analysis is highlighted in bold.

Abbreviations: OR - odds ratio, CI - confidence interval.