Table 1. Clinicopathological characteristics and correlation with PD-L1 and PD-1 expression.
| Characteristic | All cases | Tumoral PDL1 | Stromal PDL1 | Stromal PD1 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Negative | Positive | Negative | Positive | Negative | Positive | ||||||
| Cases (%) | Cases (%) | Cases (%) | p | Cases (%) | Cases (%) | p | Cases (%) | Cases (%) | p | ||
| Overall | 27 (100) | 22 (81) | 5 (19) | 11 (41) | 16 (59) | 10 (37) | 17 (63) | ||||
| Sex | |||||||||||
| Male | 12 (44) | 10 (45) | 2 (40) | 1.00* | 4 (36) | 8 (50) | 0.70* | 4 (40) | 8 (47) | 1.00* | |
| Female | 15 (56) | 12 (55) | 3 (60) | 7 (64) | 8 (50) | 6 (60) | 9 (53) | ||||
| Age at diagnosis | |||||||||||
| Age ≤60 year | 13 (48) | 12 (55) | 1 (20) | 0.33* | 8 (73) | 5 (31) | 0.03** | 5 (50) | 8 (47) | 1.00* | |
| Age >60 year | 14 (52) | 10 (45) | 4 (80) | 3 (27) | 11 (69) | 5 (50) | 9 (53) | ||||
| Tumor size, thickness | N=23 | N=20 | N=3 | N=10 | N=13 | N=9 | N=14 | ||||
| Median [range], mm | 1.0 [0.1-16.0] | 0.9 [0.2-5.0] | 6.0 [0.1-16.0] | 0.40& | 0.8 [0.2-5.0] | 1.4 [0.1-16.0] | 0.65& | 0.6 [0.2-5.0] | 1.2 [0.1-16.0] | 0.56& | |
| Tumor size, LBD | N=24 | N=19 | N=5 | N=10 | N=14 | N=9 | N=15 | ||||
| Median [range], mm | 9.5 [2.0-30.0] | 10.0 [2.0-30.0] | 6.0 [5.0-20.0] | 0.89& | 9.5 [2.0-12.0] | 10.0 [2.0-30.0] | 0.44& | 7.0 [2.0-15.0] | 10.0 [2.0-30.0] | 0.48& | |
| Location | |||||||||||
| Epibulbar | 20 (74) | 17 (77) | 3 (60) | 0.58* | 9 (82) | 11 (69) | 0.66* | 10 (100) | 10 (59) | 0.03* | |
| Non-epibulbar | 7 (26) | 5 (23) | 2 (40) | 2 (18) | 5 (31) | 0 (0) | 7 (41) | ||||
| cTNM** | |||||||||||
| T1 | 20 (74) | 17 (77) | 3 (60) | 0.58* | 10 (82) | 11 (69) | 0.66* | 10 (100) | 10 (59) | 0.03* | |
| T2 | 7 (26) | 5 (23) | 2 (40) | 2 (18) | 5 (31) | 0 (0) | 7 (41) | ||||
| Local recurrence | |||||||||||
| No | 16 (59) | 13 (59) | 3 (60) | 1.00* | 6 (55) | 10 (63) | 0.71* | 8 (80) | 8 (47) | 0.12* | |
| Yes | 11 (41) | 9 (41) | 2 (40) | 5 (45) | 6 (38) | 2 (20) | 9 (53) | ||||
| Distant metastasis | |||||||||||
| No | 23 (85) | 21 (95) | 2 (40) | 0.01* | 11 (100) | 12 (75) | 0.12* | 10 (100) | 13 (76) | 0.27* | |
| Yes | 4 (15) | 1 (5) | 3 (60) | 0 (0) | 4 (25) | 0 (0) | 4 (24) | ||||
LBD = largest basal diameter. cTNM = clinical TNM stage, based on the first occurring conjunctival melanoma. P value calculation: * = Fischer exact test; ** = Pearson's chi-square; & = Mann Whitney U test. Italic P values are ≤ 0.05.